【求助】IKK-NF-κB通路抑制剂NBD
丁香园论坛
原理如下:
IKKγ binds to specific sequences on IKKα and IKKβ, forming the IKK complex. The IKK complex phosphorylates downstream signaling molecules during NF-κB activation. The IKKγ inhibitory peptide contains an IKKα and IKKβ consensus binding sequence, called NEMO binding domain or NBD. When IKKα and IKKβ are bound to the IKKγ NBD peptide, they can not bind to IKKγ. Thus the formation and function of the IKK complex is blocked.
图解如下:
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