Mass Spectrometric Quantification of F2-Isoprostanes as Indicators of Oxidant Stress
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Free radicals derived primarily from molecular oxygen are believed to play an important role in a variety of disease processes including atherosclerosis, cancer, and neurodegenerative disorders (1 ). Much of the evidence for this association, however, is indirect largely because of limitations in techniques currently available to quantify free radicals or their products in biological systems (2 ,3 ). This is a particular problem when assessing oxidant injury in vivo in humans.
