[Nature] RNAi研究专题

Cells utilize RNA interference (RNAi) to regulate protein expression in many contexts. The discovery of RNAi has transformed our understanding of gene regulation as well as our ability to manipulate it. Gathered here is a selection of research and comment on RNAi published in the pages of Nature , including groundbreaking research from today"s issue. This focus also brings together news and reviews from across the Nature Publishing Group, and a fantastic animation offers the chance to view the RNAi process in action.

RESEARCH
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Soutschek J. et al .
Nature 432 , 173 - 178 (11 Nov 2004)

Processing of primary microRNAs by the Microprocessor complex
Denli A.M. et al .
Nature 432 , 231 - 235 (11 Nov 2004)

The Microprocessor complex mediates the genesis of microRNAs
Gregory R.I. et al .
Nature 432 , 235 - 240 (11 Nov 2004)

A pancreatic islet-specific microRNA regulates insulin secretion 226
Poy M.N. et al .
Nature 432 , 226 - 230 (11 Nov 2004)

NEWS AND VIEWS
Medicine: A cholesterol connection in RNAi
Rossi J.J.
Nature 432 , 155 - 156 (11 Nov 2004)

INSIGHT
Nature Insight on RNA interference
A collection of reviews exploring the ramifications and potential uses of RNAi.

ARTICLES
MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode
Chang S., Johnston R.J. Jr., Frokjaer-Jensen C., Lockery S. & Hobert O.
Nature 430 , 785 - 789 (12 Aug 2004)

Role of transposable elements in heterochromatin and epigenetic control
Lippman Z. et al .
Nature 430 , 471 - 476 (22 Jul 2004)

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain
Ma J.B., Ye K. & Patel D.J.
Nature 429 , 318 - 322 (20 May 2004)

A large-scale RNAi screen in human cells identifies new components of the p53 pathway
Berns K. et al.
Nature 428, 431 - 437 (25 Mar 2004)