CD4分子
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CD4 分子
CD4
常用单克隆抗体或代号：T4，Leu3a
主要表达细胞：Tsub，Msub，Thysub T细胞
分子质量(kDa)和结构：gp55(IgSF)
功 能：与MCHn类分子结合，信号转导，HIV受体
CD4
Aka OKT4, T helper/inducer
On chromosome #12p
Nonpolymorphous glycoproteins belonging to immunoglobulin superfamily
Serves as HIV receptor on T cells (as do chemokine receptors CCR5 and CXCR4), macrophages, brain
CD4+ T cells are killed by HIV
Coreceptor in MHC class II-restricted antigen induced T cell activation
Binds to nonpolymorphic region of class I molecules; may increase avidity of cell-cell interactions
Positive staining (normal): thymocytes (80-90%), mature T cells (65%, T helper and CD4/CD8+ thymocytes), macrophages, Langerhans cells, dendritic cells, granulocytes
Positive staining (disease): pityriasis lichenoides
Micro images: acute demyelinating disease, extranodal NK/T cell lymphoma, nasal type
