CD28分子

Cell adhesion molecule; co-receptor for B cell-T cell cooperation

Promotes T cell activation

Receptor for CD80 (B7) & CD86 (BB1), found on activated B cells

Constitutive, high abundance, low affinity receptor; opposite signals are mediated by CTLA4 (CD152)

Result of T cell antigen stimulation depends on sum of effects of T cell receptor, CD28 and its ligand, CTLA4 and its ligand

CD8+, CD28+ T cells mediate antigen specific cytotoxic T cells (class I restricted) (90% of CD8+ T cells)

CD8+, CD28- T cells mediate suppressor T cells (10% of CD8+ T cells)

Positive staining (normal): CD4+ T cells (95%), CD8+ T cells (50%); activated B cells, plasma cells

Reference: 186760