mRNA: Detection by In Situ and Northern Hybridization
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direct assessment of the presence, distribution, and modulation of specific RNA species under different physiological conditions (4 ,5 );
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molecular investigations of potential mRNA splice variants and region-specific heterogeneity in multimeric-receptor subunit expression (6 ,7 );
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indirect identification of receptor-expression to add credence to the existence of that receptor when highly selective ligands are unavailable for receptor binding site localization studies (8 ); and
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investigation of molecular changes in pathological states and the possible modes of action of drugs used to treat such conditions (9 –11 ).
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