CD60a/CD60b/CD60c分子
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CD60a/CD60b/CD60c 分子
CD60a
常用单克隆抗体或代号:GD3(R24)
主要表达细胞: Tsub,Pt,Bsub,Mac,M,C[CH0]
功 能: T细胞活化增殖;诱导凋亡过程中线粒体通透性的改变;恶性黑素瘤的标志
CD60b
常用单克隆抗体或代号:9-O-acety-GD3 (UM4D4,M-T6004)
主要表达细胞:Tsub,Ba,Mac,M,Ep[CH0]
功 能: T细胞辅助功能,B细胞活化抗原;与乳腺癌、黑素瘤等某些肿瘤有关
CD60c
常用单克隆抗体或代号:7―O-acetyl―GD3(U5)
主要表达细胞:Tsub,Tsub[CHO]
功 能: T细胞活化增殖
CDw60
Antibodies provide costimulatory/comitogenic signals for T cells
Expressed on most T cells in autoimmune lesions
Positive staining (normal): platelets, T subset, thymic epithelium, activated keratinocytes, synovial fibroblasts, glomeruli, smooth muscle cells, astrocytes
CD60a
GD3 - carbohydrate structure
CD60b
9-O-acetyl-GD3 - carbohydrate structure
CD60c
7-O-acetyl-GD3 - carbohydrate structure