Protein Binding of Psychotropic Drugs: Equilibrium Dialysis and Lipophilicity Correlations
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Binding of drugs to plasma protein has been known for many years to be significant in both drug effects and pharmacokinetics (Goldstein, 1949; Gillette, 1973; Curry, 1980; Meyer and Guttman, 1968; Vallner, 1974). However, in spite of rigorous study, binding remains contentious and poorly understood. This review is concerned with binding phenomena concernmg psychotropic drugs, methods of study, and pharmacological significance. Tiβue binding is also considered. Special attention is given to the most popular aβeβment technique—equilibrium dialysis. This technique has recently undergone rigorous reevaluation.