后期促进复合物(anaphase-promoting complex,APC)

互联网2013-11-15

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APC即遍在蛋白连接酶(ubiquitin ligase, E3)复合物。 E3通常是一种复合体,由多亚基组成。例如从非洲爪蟾卵细胞中分离的周期蛋白B的E3至少含有8个不同的亚基。APC激发E2-遍在蛋白复合物同有丝分裂周期蛋白破坏框结合, 然后激发遍在蛋白同破坏框C-末端的赖氨酸残基结合，此过程不断循环使遍在蛋白多聚化。

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