Antibodies Against Malondialdehyde-Modified Proteins: Induction and ELISA Measurement of Specific Antibodies

Polyunsaturated fatty acids undergo in vivo oxidative damage called lipid peroxidation, breaking down to lipid hydroperoxides and various secondary products (1). Increase in lipid peroxides have been reported, for example, in radiation damage, diabetes, hyperlipidemia, and vascular diseases, and there is considerable interest in the relation between oxidative stress and development of atherosclerosis (2,3).