CD31分子
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CD31 分子
CD31
常用单克隆抗体或代号： SG134,TM3,HEC- 75;(PECAM、EndoCAM)
主要表达细胞： Pt,M,G,B,NK,Tsub [AS]
分子质量(kDa)和结构： gp140,血小板GPⅡa(IgSF)
功 能： 嗜同性或嗜异性(与CD38互为受体)粘附,炎症,En功能
CD31
Aka platelet endothelial cell adhesion molecule, PECAM-1
Encoded on #17
Most sensitive and specific endothelial marker in paraffin sections
Important role in diapedesis step of leukocyte emigration in inflammation; also angiogenesis
Note: don’t confuse CD31+ macrophages (granular, membranous expression) with a vascular tumor, AJSP 2001;25:1167
Sensitive for malignant vascular tumors; may be less sensitive for benign lesions
Interpretation: membranous stain (not cylasmic); endothelium is a positive internal control
Positive staining (normal): endothelium, platelets, macrophages and Kupffer cells, granulocytes, T / NK cells, lymphocytes, megakaryocytes, fibroblasts, osteoclasts, neutrophils
Positive staining (tumors): epithelioid hemangioendothelioma; epithelioid sarcoma-like hemangioendothelioma (AJSP 2003;27:48); other vascular tumors, histiocytic malignancies, plasmacytomas; rare carcinomas and sarcomas
Micro images: epithelioid angiosarcoma (figure 1A)
Micro images (AJSP subscribers): epithelioid sarcoma-like hemangioendothelioma, epithelioid hemangioendothelioma, epithelioid angiosarcoma, CD31+ macrophages, malignant histiocytosis
Micro images (Hum Path subscribers): hepatic cavernous hemangiomas (figure 2B)
Micro images (Mod Path subscribers): angiosarcoma (figure E)
References: AJSP 2001;25:684, Mod Path 2002:15;434
