【进展】早期胸腺祖细胞具有髓系分化潜能
丁香园论坛
1609
Nature 452, 764-767 (10 April 2008)
The earliest thymic progenitors for T cells possess myeloid lineage potential
J. Jeremiah Bell1 & Avinash Bhandoola1
Abstract:There exists controversy over the nature of haematopoietic progenitors of T cells. Most T cells develop in the thymus, but the lineage potential of thymus-colonizing progenitors is unknown. One approach to resolving this question is to determine the lineage potentials of the earliest thymic progenitors (ETPs). Previous work has shown that ETPs possess T and natural killer lymphoid potentials, and rare subsets of ETPs also possess B lymphoid potential1, suggesting an origin from lymphoid-restricted progenitor cells. However, whether ETPs also possess myeloid potential is unknown. Here we show that nearly all ETPs in adult mice possess both T and myeloid potential in clonal assays. The existence of progenitors possessing T and myeloid potential within the thymus is incompatible with the current dominant model of haematopoiesis, in which T cells are proposed to arise from lymphoid-2. Our results indicate that alternative models for lineage commitment during haematopoiesis must be considered.
内容简介：现有模型认为，T细胞来源于淋巴细胞样限制性祖细胞（lymphoid-restricted progenitors）。先前有研究显示，早期胸腺祖细胞（earliest thymic progenitors，ETPs）除了具有T细胞和NK细胞样分化潜能外，极少数ETPs具有B淋巴细胞样分化潜能，提供了淋巴细胞样祖细胞的来源线索。本研究表明，在成年鼠体内，几乎所有的ETPs都具有T系和髓系分化潜能。胸腺中存在T系和髓系分化潜能的祖细胞（progenitors），对现有ETPs分化模型发起了挑战。
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The earliest thymic progenitors for T cells possess myeloid lineage potential
J. Jeremiah Bell1 & Avinash Bhandoola1
Abstract:There exists controversy over the nature of haematopoietic progenitors of T cells. Most T cells develop in the thymus, but the lineage potential of thymus-colonizing progenitors is unknown. One approach to resolving this question is to determine the lineage potentials of the earliest thymic progenitors (ETPs). Previous work has shown that ETPs possess T and natural killer lymphoid potentials, and rare subsets of ETPs also possess B lymphoid potential1, suggesting an origin from lymphoid-restricted progenitor cells. However, whether ETPs also possess myeloid potential is unknown. Here we show that nearly all ETPs in adult mice possess both T and myeloid potential in clonal assays. The existence of progenitors possessing T and myeloid potential within the thymus is incompatible with the current dominant model of haematopoiesis, in which T cells are proposed to arise from lymphoid-2. Our results indicate that alternative models for lineage commitment during haematopoiesis must be considered.
内容简介：现有模型认为，T细胞来源于淋巴细胞样限制性祖细胞（lymphoid-restricted progenitors）。先前有研究显示，早期胸腺祖细胞（earliest thymic progenitors，ETPs）除了具有T细胞和NK细胞样分化潜能外，极少数ETPs具有B淋巴细胞样分化潜能，提供了淋巴细胞样祖细胞的来源线索。本研究表明，在成年鼠体内，几乎所有的ETPs都具有T系和髓系分化潜能。胸腺中存在T系和髓系分化潜能的祖细胞（progenitors），对现有ETPs分化模型发起了挑战。
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