MRI of Experimental Gliomas

Malignant gliomas are the most frequent primary brain tumours and they are associated with a grim prognosis. In order to elucidate the biological properties of these tumours and to assess treatment responses, valid animal models are needed. We have developed a model where human glioma specimens are operated into the brains of immunodeficient animals. Tumour development is followed by MR imaging and proton spectroscopy. In this chapter, operating procedures and the MR techniques are presented.