Experimental Stroke Research: The Contributions of In Vivo MRI

Stroke is a disease that develops from the very acute time point of first symptoms during the next several hours and further to a chronic time period of days or even weeks. During this evolution process, a whole series of pathophysiological events takes place. Therefore, the disease is characterized by a continuously changing pathophysiological pattern. In consequence, as the disease develops over time, different imaging modalities must be chosen to accurately describe the status of stroke. In the present chapter, we have divided the evolution of stroke into various dominant steps of the cascade of events, with corresponding time windows. Choice of MRI variables for depiction of the most important aspects during these time windows are presented and their information content is discussed for diagnosis and for investigations into a better understanding of the underlying mechanisms for the disease as well as the relevance of these imaging tools in success assessments for therapeutic strategies.