Molecular Methods for Detecting Ulcerogenic Strains of H. pylori
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Certain nonconserved genotypic and phenotypic characteristics of H. pylori are associated with increased risk of peptic ulceration in the human host. These characteristics can be divided into two groups: first, those relating to vacuolating cytotoxin activity (1 ,2 ), and differences in the gene encoding the cytotoxin, vacA (3 ); second, those relating to the cytotoxin-associated gene, cagA (4 ,5 ).
![vacA/vacA蛋白Recombinant Helicobacter pylori Vacuolating cytotoxin autotransporter (vacA)重组蛋白Vacuolating cytotoxin autotransporter [Cleaved into: Vacuolating cytotoxin; Vacuolating cytotoxin translocator]蛋白](https://img1.dxycdn.com/p/s14/2024/0914/795/0844698182989384381.jpg!wh200)
