Determination of Co-Receptor Usage of HIV-1
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In addition to CD4, HIV-1 uses chemokine receptors for entry in their target cells. The most important chemokine receptors in this respect are β-chemokine receptor 5 (CCR5) and α-chemokine receptor 4 (CXCR4). Coreceptor usage is an important feature of the biological phenotype of HIV-1 variants. In this chapter, methods are described to determine the co-receptor usage of HIV-1 variants.
