【进展|热点】nature medicine 最新研究表明一种具有干细胞特性的人记忆T细胞亚群
丁香园论坛
1295
A human memory T cell subset with stem cell–like properties
Luca Gattinoni，Enrico Lugli, Yun Ji et al.
nature medicine 2011;17(10):1290-1298
Immunological memory is thought to depend on a stem cell–like, self-renewing population of lymphocytes capable of
differentiating into effector cells in response to antigen re-exposure. Here we describe a long-lived human memory T cell population that has an enhanced capacity for self-renewal and a multipotent ability to derive central memory, effector memory and effector T cells. These cells, specific to multiple viral and self-tumor antigens, were found within a CD45RO?, CCR7+, CD45RA+, CD62L+, CD27+, CD28+ and IL-7Ra+ T cell compartment characteristic of naive T cells. However, they expressed large amounts of CD95, IL-2Rb, CXCR3, and LFA-1, and showed numerous functional attributes distinctive of memory cells. Compared with known memory populations, these lymphocytes had increased proliferative capacity and more efficiently reconstituted immunodeficient hosts, and they mediated superior antitumor responses in a humanized mouse model. The identification of a human stem cell–like memory T cell population is of direct relevance to the design of vaccines and T cell therapies.
Luca Gattinoni，Enrico Lugli, Yun Ji et al.
nature medicine 2011;17(10):1290-1298
Immunological memory is thought to depend on a stem cell–like, self-renewing population of lymphocytes capable of
differentiating into effector cells in response to antigen re-exposure. Here we describe a long-lived human memory T cell population that has an enhanced capacity for self-renewal and a multipotent ability to derive central memory, effector memory and effector T cells. These cells, specific to multiple viral and self-tumor antigens, were found within a CD45RO?, CCR7+, CD45RA+, CD62L+, CD27+, CD28+ and IL-7Ra+ T cell compartment characteristic of naive T cells. However, they expressed large amounts of CD95, IL-2Rb, CXCR3, and LFA-1, and showed numerous functional attributes distinctive of memory cells. Compared with known memory populations, these lymphocytes had increased proliferative capacity and more efficiently reconstituted immunodeficient hosts, and they mediated superior antitumor responses in a humanized mouse model. The identification of a human stem cell–like memory T cell population is of direct relevance to the design of vaccines and T cell therapies.
