CD46分子
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2030
CD46 分子
CD46
常用单克隆抗体或代号： HULYM5,J48
主要表达细胞： 广泛,Leu,Pt [NL]
分子质量(kDa)和结构： gp56- 66,膜辅助因子蛋白(MCP)
功 能： 调节补体活化,裂解C3b ,C4b膜辅助因子蛋白
CD46
Aka membrane cofactor protein (MCP)
Cofactor for Factor I proteolytic cleavage of C3b and C4b; prevents inappropriate complement activation, especially via alternative pathway, by limiting formation and function of C3 convertases
Receptor for measles virus and HHV-6
Has multiple isoforms
Acrosomal CD46 is exposed on sperm head at capacitation; may help fuse spermatozoa and oocyte
Positive staining (normal): all cells except erythrocytes
