丁香实验_LOGO
登录
提问
我要登录
|免费注册
点赞
收藏
wx-share
分享

PrP-Deficient Mice in the Study of Transmissible Spongiform Encephalopathies

互联网

569
The Transmissible Spongiform Encephalopathies (TSEs), such as scrapre, BSE, and Creutzfeldt-Jakob disease, are associated with alterations in the neural membrane protein or prion protein (PrP). This chapter will outline the gene targeting approaches that have been used to mutate the murine PrP gene, resulting in mice with reduction or absence of the PrP protein. It will then describe how these transgenuic animals can contribute to our understanding of the role of PrP in agent replication, the pathology of the TSEs, and the normal function of PrP
提问
扫一扫
丁香实验小程序二维码
实验小助手
丁香实验公众号二维码
扫码领资料
反馈
TOP
打开小程序