In Vitro and In Vivo Models to Study Chemokine Regulation of Angiogenesis

Angiogenesis is defined as the generation of new blood vessels from preexisting ones. Physiologic angiogenesis is a controlled and fundamental process during embryonic development, being rare in the adult and limited to conditions such as wound healing and menstrual cycle. If regulation of the process is lost, persistent angiogenesis may occur and contribute to pathologic states such as cancer, rheumatoid arthritis, and diabetes mellitus.