Use of the Herpes Simplex Viral Genome to Construct Gene Therapy Vectors
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A trilaminar lipid envelope, in which are embedded 10 viral glycoproteins-these are responsible for several functions including receptor-mediated cellular entry (2 –5 ).
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A matrix of proteins, the tegument, which form a layer between the envelope and the underlying capsid. Functions of the tegument proteins include: induction of viral gene expression (6 –8 ); shutoff of host protein synthesis immediately following infection (9 –12 ); virion assembly functions.
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An icosadeltahedral capsid, typical of the herpesvirus family (13 ,14 ).
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A core of toroidal double-stranded DNA (dsDNA) (14 –16 ).
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