CD66a
Aka CEACAM1, biliary glycoprotein, BGP, C-CAM
Primordial protein of carcinoembryonic antigen (CEA) family
Cell adhesion molecule capable of activating neutrophils; may regulate CD11/CD18 activity
Receptor for Neisseria gonorrhea and N. meningitidis
Downregulated in colorectal, endometrial and hepatocellular carcinomas; supplementation may cause tumor regression in vitro or in rodents
Downregulated in Gleason grade 4/5 prostate carcinoma, Hum Path 2002;33:290
Positive staining (normal): granulocytes, epithelial cells, prostate glands and ducts (dense), bile canaliculi between liver cells
Positive staining (disease): low grade prostatic carcinoma
Negative staining: prostate carcinoma, Gleason grade 4/5
Micro images (Hum Path subscribers): Prostate: A-normal, B-Gleason grade 3, C-Gleason grade 4, normal liver (figure F)
CD66b
Aka CEA gene member 6; formerly CD67
Capable of activating neutrophils; may regulate CD11/CD18 adhesion activity
Positive staining (normal): granulocytes
Positive staining (disease): chronic myelogenous leukemia
CD66c
Aka noncross reactive antigen (NCA)
Capable of activating neutrophils; may regulate CD11/CD18 adhesion activity
Positive staining (normal): granulocytes
CD66d
Capable of activating neutrophils and functions as a receptor for Neisseria gonorrhea and N. meningitidis
May play a signaling role and regulate adhesion activity of CD11/CD18 in neutrophils
Positive staining (normal): granulocytes
CD66e
Aka CEA, carcinoembryonic antigen
May play a role in the process of metastasis of cancer cells
Serum marker of tumor burden, relapse
Removed by hepatic Kupffer cells via a specific receptor.
Uses: 85% sensitive, 96% specific for lung adenocarcinomas vs. mesotheliomas; diffuse cylasmic staining with membrane enhancement
Positive staining (normal): biliary tract, colon (fetal), epithelial cells (apical surfaces), GI adenocarcinomas (endodermally derived), granulocytes, small intestinal crypts; small intestinal goblet cell mucin (not intracylasmic)
Positive staining (tumors): colonic and lung adenocarcinoma, medullary thyroid carcinoma
Variable staining: breast carcinoma, endometrial carcinoma, neuroendocrine carcinoma, urothelial carcinoma
Negative staining: hepatocellular carcinoma, mesothelioma, ovarian carcinoma, prostate adenocarcinoma, renal cell carcinoma, thyroid carcinoma other than medullary
CD66f
Aka pregnancy-specific glycoprotein
May be involved in immune regulation, protection of fetus from maternal immune system
Low levels in maternal blood predict spontaneous abortion
Positive staining (normal): syncytiotrophoblasts, fetal liver, myeloid cell lines
Reference: 176390