CD66a/CD66b/CD66c/CD66d/CD66e/CD66f/CD67分子
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CD66a/CD66b/CD66c/CD66d/CD66e/CD66f/CD67 分子
CD66a
常用单克隆抗体或代号： BGP- 1
主要表达细胞： G,En [M]
分子质量(kDa)和结构： gp180- 200(胆汁糖蛋白- 1)(IgSF)
功 能： 嗜同性结合,也可识别CD62E
CD66b
常用单克隆抗体或代号： MF25.1;(P100,原CD67,CGM6)
主要表达细胞： G [M]
分子质量(kDa)和结构： gp95- 100,(GPT连接,IgSF)
功 能： CEA家族成员
CD66c
常用单克隆抗体或代号： NCA(无交叉反应抗原)
主要表达细胞： G [M]
分子质量(kDa)和结构： gp90- 95(IgSF)
功 能： CEA家族成员
CD66d
常用单克隆抗体或代号： CGM1
主要表达细胞： G [M]
分子质量(kDa)和结构： Gp30(IgSF)
功 能： CEA家族成员
CD66e
常用单克隆抗体或代号： CLB- gran/10(CEA)
主要表达细胞： G,My,上皮 [M]
分子质量(kDa)和结构： gp180- 200(IgSF)
功 能： 粘附,CEA家族成员
CD66f
常用单克隆抗体或代号： PSG(妊娠特异性抗原)
主要表达细胞： G,M,Mac [M]
分子质量(kDa)和结构： gp54-72
功 能：可能与成功妊娠有关，保护胎儿免受母体免疫系统的损害
CD67
常用单克隆抗体或代号： 改为CD66b
CD66a
Aka CEACAM1, biliary glycoprotein, BGP, C-CAM
Primordial protein of carcinoembryonic antigen (CEA) family
Cell adhesion molecule capable of activating neutrophils; may regulate CD11/CD18 activity
Receptor for Neisseria gonorrhea and N. meningitidis
Downregulated in colorectal, endometrial and hepatocellular carcinomas; supplementation may cause tumor regression in vitro or in rodents
Downregulated in Gleason grade 4/5 prostate carcinoma, Hum Path 2002;33:290
Positive staining (normal): granulocytes, epithelial cells, prostate glands and ducts (dense), bile canaliculi between liver cells
Positive staining (disease): low grade prostatic carcinoma
Negative staining: prostate carcinoma, Gleason grade 4/5
Micro images (Hum Path subscribers): Prostate: A-normal, B-Gleason grade 3, C-Gleason grade 4, normal liver (figure F)
CD66b
Aka CEA gene member 6; formerly CD67
Capable of activating neutrophils; may regulate CD11/CD18 adhesion activity
Positive staining (normal): granulocytes
Positive staining (disease): chronic myelogenous leukemia
CD66c
Aka noncross reactive antigen (NCA)
Capable of activating neutrophils; may regulate CD11/CD18 adhesion activity
Positive staining (normal): granulocytes
CD66d
Capable of activating neutrophils and functions as a receptor for Neisseria gonorrhea and N. meningitidis
May play a signaling role and regulate adhesion activity of CD11/CD18 in neutrophils
Positive staining (normal): granulocytes
CD66e
Aka CEA, carcinoembryonic antigen
May play a role in the process of metastasis of cancer cells
Serum marker of tumor burden, relapse
Removed by hepatic Kupffer cells via a specific receptor.
Uses: 85% sensitive, 96% specific for lung adenocarcinomas vs. mesotheliomas; diffuse cylasmic staining with membrane enhancement
Positive staining (normal): biliary tract, colon (fetal), epithelial cells (apical surfaces), GI adenocarcinomas (endodermally derived), granulocytes, small intestinal crypts; small intestinal goblet cell mucin (not intracylasmic)
Positive staining (tumors): colonic and lung adenocarcinoma, medullary thyroid carcinoma
Variable staining: breast carcinoma, endometrial carcinoma, neuroendocrine carcinoma, urothelial carcinoma
Negative staining: hepatocellular carcinoma, mesothelioma, ovarian carcinoma, prostate adenocarcinoma, renal cell carcinoma, thyroid carcinoma other than medullary
CD66f
Aka pregnancy-specific glycoprotein
May be involved in immune regulation, protection of fetus from maternal immune system
Low levels in maternal blood predict spontaneous abortion
Positive staining (normal): syncytiotrophoblasts, fetal liver, myeloid cell lines
Reference: 176390
CD67
Recognizes non-specific cross-reactive antigens present on granulocytes
May have role in neutrophil activation
