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CD1a/CD1b/CD1c/CD1d分子

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2658
CD1a/CD1b/CD1c/CD1d分子
 
CD1a
常用单克隆抗体或代号:T6,Leu6
主要表达细胞:Thy,DCsub,LHC,Bsub T细胞
分子质量(kDa)和结构:gp49(IgSF)
功    能:与β2m组成MHCI类样分子,有抗原提呈功能
 
CD1b
常用单克隆抗体或代号:WM-25,4A7.6,NUT2
主要表达细胞:Thy,DC,LHC,Bsub T细胞
分子质量(kDa)和结构:gP45(IgSF)
功    能:与β2m组成MHCI类样分子,有抗原提呈功能
 
CD1c
常用单克隆抗体或代号:L161,M241,7(26
主要表达细胞:Thy,IX;sub,LHC,Bsub T细胞
分子质量(kDa)和结构:gp43(IgSF)
功    能:与β2m组成MHCI类样分子,有抗原提呈功能
 
CD1d
主要表达细胞:Thy,DC,LHC,Bsub,肠道上皮细胞 T细胞
分子质量(kDa)和结构:(IgSF)
功    能:与β2m组成MHCI类样分子,有抗原提呈功能
 
CD1
Family of non-polymorphic MHC class I-like glycoproteins
Also member of immunoglobulin superfamily
On chromosome 1q22-23 (not MHC linked)
Has 5 different subsets, all noncovalently associated with 12 kd beta 2 microglobulin
Function: restrict T cell responses to certain antigens; may mediate thymic T cell development
Positive staining (normal): cortical thymocytes (70%), activated T cells, Langerhans cells, interdigitating dendritic cells
Positive staining (disease): pre T ALL with cortical thymocyte phenotype; Langerhans cell histiocytosis
Negative staining: mature peripheral T cells
 
CD1a
Positive staining (normal): Dendritic cells in dermis/epidermis of benign inflammatory skin disorders
Positive staining (disease): Langerhans cell histiocytosis (fairly specific), myeloid leukemias, some B cell malignancies; dendritic cells in most peripheral cutaneous T cell lymphomas, AJCP 2001;116:72
Negative staining: normal B cells, most cutaneous peripheral B cell lymphomas (? reflects replacement of reactive pattern containing dendritic cells with a neoplastic pattern of B cells)
Micro images:  Langerhans cell histiocytosis
Micro images (AJSP subscribers): pulmonary Langerhans cell histiocytosis
Micro images (Hum Path subscribers): Langerhans cell histiocytosis
References:  AJSP 2001;25:630
 
CD1b
 
Positive staining (disease): myeloid leukemias and some B cell malignancies
Negative staining: normal B cells
 
CD1c
Positive staining (normal): subset of normal peripheral B cells
Positive staining (disease): myeloid leukemias and some B cell malignancies
Negative staining: normal B cells
 
CD1d
Positive staining (normal): thymus (low levels), bowel

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