CD20分子
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CD20 分子
CD20
常用单克隆抗体或代号： B1,Leu16
主要表达细胞： B,FDC [B]
分子质量(kDa)和结构： p33(非糖基化穿膜磷蛋白)
功 能： Ca2+通道,调节B细胞活化和增殖
CD20
Aka L26
33kd phosphoprotein with 3 hydrophobic regions that traverse the cell membrane, creating a structure similar to an ion channel
Delivers early signal in B cell activation, allowing resting B cells to respond to later antigens
Rituximab is a chimeric murine-human anti-CD20 antibody used for treatment of B cell lymphomas
Uses: commonly used marker for B cells
Positive staining (normal): Most B cells (after CD19 and CD10 expression, before CD21/22 expression and surface immunoglobulin expression), retained on mature B cells until plasma cell development; also follicular dendritic cells
Positive staining (disease): 90% of B cell lymphomas, 40% of pre B ALL/LBL; 80% of lymphocyte predominant Hodgkin’s lymphoma, dimly expressed in T cells (benign and neoplastic), spindle cell thymomas
Negative staining: non-hemaoietic cells, most T cells, plasma cells
Micro images: large B cell lymphoma, CNS diffuse large B cell lymphoma (figure A), lymphoplasmacytic lymphoma/ Waldenström macroglobulinemia in brain-figure D
Micro images (Mod Path subscribers): post-transplant lymphoproliferative disorder
References: Mod Path 2002;15:647
