Epitope Mapping Using Multipin Peptide Synthesis
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Multiple peptide synthesis gives access to a set of reagents that permit thorough answers to such questions as: Where are all the linear epitopes in this protein? How long is the critical part of each epitope? Which epitopes are commonly recognized and which are rarely recognized? What are the affinities for each epitope? Which amino acids in the epitope are in contact with the antibody/TCR/MHC molecule? What variants of the epitope are still recognized by the antibody/TCR/MHC molecule? Which peptides are antagonistic peptides for this epitope?
