Animal Models of Overeating

Obesity has become a major health and economic burden, and the development of new treatments is urgently needed. Initially, such treatments involve use of animal models, and the purpose of this chapter is to describe some of the most useful models, why one might be chosen over another to address a particular question, and any procedural pitfalls. I restrict the discussion to rats and mice, used in the overwhelming majority of preclinical studies, and more specifically to protocols of diet-induced obesity and those that emulate binge eating.