Experimental Models of Visceral Pain

Visceral pain models are used to study afferent nerve traffic during noxious stimulation at the level of the visceral organ. This chapter provides details on several in vitro and in vivo models of organs in the gastrointestinal and genitourinary tract that use electrophysiological recordings of afferent nerve fibres in order to directly characterize stimulus-response relationships. These models can also be used to investigate stimulus-response patterns during physiological (nonpainful) stimulation of the visceral organs or during exposure to pathological stimuli, such as inflammatory mediators during inflammation of the visceral organ.