Human Experimental Pain Models 1: The Ultraviolet Light UV-B Pain Model
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The UV-B pain model utilizes ultraviolet light to induce a small area of inflammation allowing assessment of mechanical and
thermal thresholds. Pharmacologic testing has mainly focused on reduction of primary hyperalgesia, although the effect of
analgesics on secondary hyperalgesia has also been investigated. The model requires an instrument to precisely generate controlled
UV-B tissue hyperalgesia. Initially, a minimum dose to induce tissue hyperalgesia is determined; subsequently, dosages are
delivered in set quantities. Tissue is then assessed for inflammation using color Doppler imaging or flare measurements. Heat
pain thresholds and pain tolerance are often evaluated using a commercially available thermal sensory testing device. Analgesics
can be administered to determine the influence on these clinical endpoints.