CD41分子
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CD41 分子
CD41
常用单克隆抗体或代号： PBM6.4,PL273(integrin a Ⅱb)
主要表达细胞： Pt,Meg [Pt]
分子质量(kDa)和结构： gp120/23
功 能： 血小板凝集和活化Fb,结合ECM(FB,vWF)的受体,与CD61组成二聚体
CD41
Aka platelet GPIIb
Receptor for fibrinogenin, von Willebrand factor and fibronectin
Mutations cause thrombasthenia
Positive staining (normal): platelets, megakaryocytes
Positive staining (disease): AML M7, blasts in transient myeloproliferative disorder
