Rapid Identification of Chromosomes Using Primed In Situ Labeling (PRINS)

Primed in situ labeling (PRINS) was introduced by Koch and colleagues (1 ) for the visualization of chromosome centromeres. The concept is based on the knowledge that the alpha satellite repeat monomers at the human centromeres exhibit variation among chromosomes (2 ), and by targeting such variation, it is possible to obtain chromosomespecific