CD3分子
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CD3 分子
CD3
常用单克隆抗体或代号：T3，I．eu4，HCHTl
主要表达细胞：T，Thy T细胞
分子质量(kDa)和结构：γ，δ，ε，ζ，η分别为26，20， 19， 16， 2l
功 能：TCR／CD3复合体．T细胞信号转导
CD3
Aka OKT3
Function: complex (5 chains) of integral membrane glycoproteins assembled as a complex; has long cylasmic tail with antigen recognition activation motif; complex is then down regulated
Also subdivided into delta, epsilon, gamma subtypes
Cylasmic expression at early T cell differentiation, then membranous expression
Most specific T cell antibody
Positive staining (normal): thymocytes, peripheral T cells, NK cells; also Purkinje cells of cerebellum
Positive staining (disease): 80% of T cell lymphomas
Negative staining: gamma delta T cell receptors, most B cell lymphomas
Micro images: CD3 epsilon-testicular NK/T cell lymphoma (figure 3D)
Micro images (AJSP subscribers): achalasia, post-transplant lymphoproliferative disease in liver
References: AJSP 2001;25:1413
