Quantitation of First- and Second-Generation Antipsychotics by LC-MS/MS

Antipsychotic drugs are becoming a larger part of the prescription drug market. In combination with �traditional indications for prescribing these drugs, new effective therapies are proving worthwhile as well. Here, a successful method for detecting both first- and second-generation antipsychotics is presented using a solid phase extraction method and LC-MS/MS detection. This method is used for many sample matrices and can also be used for detecting antidepressants, which are often prescribed in conjunction with antipsychotics.