Immobilized Enzymes for Biomedical Applications

Immobilized enzymes were first applied in the biomedical field aiming to detect bioactive substances or to treat a disease condition. This chapter presents two approaches used for the immobilization of L-asparaginase intended for the treatment of leukemia, based on the entrapment of this enzyme in a matrix. The particulate drug carriers described in this chapter are liposomes and nanoparticles, even though the methods described here could be used for the immobilization of other enzymes with therapeutic uses.