CD7分子
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CD7 分子
CD7
常用单克隆抗体或代号：3A1，Leu9
主要表达细胞：T，NK，不成熟Mysub[T]
分子质量(kDa)和结构：gp40(IgSF)
功 能：T、NK细胞活化
CD7
Membrane glycoprotein and Fc receptor for IgM
Homologous to TCR gamma, Ig kappa
Membrane expression early during T ontogeny, before TCR rearrangement, persists until terminal stages of T cell development
Lower expression in memory T cells vs. naive T cells
Positive staining (normal): mature peripheral T cells (85%), post-thymic T cells (majority), NK cells (majority), some myeloid cells
Positive staining (disease): T cell ALL; AML (especially M4/M5), chronic myelogenous leukemia, blasts in transient myeloproliferative disorder
Negative expression: B cell ALL, Sezary syndrome, adult T cell leukemia/lymphoma
Micro images: extranodal NK/T cell lymphoma, nasal type
