CD40分子
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1911
CD40 分子
CD40
常用单克隆抗体或代号: G28- 5,EA- 5
主要表达细胞: B,M,FDC,并指细胞,上皮 [B]
分子质量(kDa)和结构: gp50(TNFR- SF)
功 能: B细胞生长、分化和记忆细胞产生,配体为CD40L,T- B相互作用
CD40
Plays a central role in regulating cell-mediated immunity and antibody mediated immunity
May mediate inflammatory component of atherogenesis
Positive staining (normal): B cells, macrophages, dendritic cells, endothelial cells, fibroblasts, keratinocytes
Positive staining (disease): carcinomas, most B cell lymphomas, B-ALL (some)
Negative staining: plasma cells