Bio-hybrid Tissue Engineering for Cellular Cardiomyoplasty: Future Directions

Cardiomyopathy induces geometric alteration of the ventricular cavity, which changes from a natural elliptical (conical) to a spherical shape. Ventricular chamber dilatation and spherical deformation are important causes of morbidity and mortality among patients with congestive heart failure. In addition, diastolic dysfunction is an important clinical problem in these cases because there is no medical or surgical specific treatment. Myocardial tissue engineering associating stem cells represent a new road and fresh hope for this heart failure population.