Cell-Free Assay System for Ras- and Rap1-Dependent Activation of MAP-Kinase Cascade
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The antisense c-Raf-1 RNA and dominant negative c-Raf-1 inhibit the Rasinduced DNA synthesis and growth (19 );
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Ras genetically posmons upstream of c-Raf-1 in Drosophila (20 ) and Caenorhabditis elegans (21 );
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Dominant negative c-Raf-1 inhibits the Ras-induced MAP kinase activation in intact cells (22 ), and
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GTP-Ras directly interacts with c-Raf-1 (23 –28 )
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