CD36分子
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CD36 分子
CD36
常用单克隆抗体或代号： 5F1,ESIVC7,OKM5
主要表达细胞： Pt,M,Mac, (B) [Pt]
分子质量(kDa)和结构： gp88,血小板GPⅣ
功 能： 结合ECM(CA、Thr),血小板粘附
CD36
Aka platelet GPIV or GPIIIb; thrombospondin receptor
Scavenger receptor for 50% of oxidized LDL and shed photoreceptor outer segments
Cell adhesion molecule in platelet adhesion and aggregation, platelet-monocyte and platelet-tumor cell interaction
Site of cytoadherence of Plasmodium falciparum infected erythrocytes to microvascular endothelial cells
CD36 deficiency frequent in sub-Saharan Africa, Asia; associated surprisingly with susceptibility to severe cerebral malaria
Development of anti-CD36 antibodies can cause serious complications in multiply transfused patients (sickle cell disease)
Positive staining (normal): platelets, macrophages, endothelial cells, early erythroid cells, megakaryocytes
Positive staining (disease): AML M4-M7
Negative staining: AML M0-M2 (usually), M3
