丁香实验_LOGO
登录
提问
我要登录
|免费注册
点赞
收藏
wx-share
分享

Abrogation of the RB-p16Tumor Suppressor Pathway in Human Lung Cancer

互联网

352
There is compelling evidence that human lung cancers are characterized by disruption of several important physiological pathways that govern proliferation, apoptosis, intracellular signaling, and cell-cell interactions. Uncontrolled cellular proliferation is one of the hallmarks of malignant tumors, and it is usually owing to abrogation of one or more checkpoints that regulate the cell cycle. The best-characterized checkpoint controls progression from G1 to S phase. The most important component of this late G1 restriction point is the protein product of the retinoblastoma gene, pRB (1). In its hypophosphorylated form, pRB binds E2F-family transcription factors. Functional inactivation of pRB leads to release of these transcription factors which then activate a program that moves the cell into S phase (1) . The most effective way to abrogate the late G1 checkpoint is a hemizygous mutation in the RB gene, with concomitant loss of the second allele-the prototypic mechanism of tumor suppressor gene inactivation. This occurs in almost all small cell lung cancers (SCLC), as well as in 15-25% of non-small cell lung cancers (NSCLC) (2 -5) .
提问
扫一扫
丁香实验小程序二维码
实验小助手
丁香实验公众号二维码
扫码领资料
反馈
TOP
打开小程序