Analyzing Molecular Interactions
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- Abstract
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Abstract
Molecular interactions are key processes that drive the functions of molecules. Large data sets of protein interaction data are being assembled that will help analyze structural and functional aspects of interactions. This chapter introduces techniques for analyzing both the structural aspects of molecular interactions and methods to use this information to understand and define biological pathways. Curr. Protoc. Bioinform. 36:8.1.1?8.1.4. © 2011 by John Wiley & Sons, Inc.
Keywords: protein?protein interactions; protein?ligand interactions; protein?water interactions; complexes; structural dynamics
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- Introduction
- Literature Cited
- Figures
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Figure 8.1.1 The crystal structure of the bacterial serine protease subtilisin with the bound water molecules observed crystallographically indicated as blue spheres. Figure courtesy of Dagmar Ringe, Brandeis University. View Image
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Literature Cited
| Literature Cited | |
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| Bartel, P.L., Roecklein, J.A., SenGupta, D., and Fields, S. 1996. A protein linkage map of Escherichia coli bacteriophage T7. Nat. Genet 12:72‐77. | |
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| Uetz, P., Giot, L., Cagney, G., Mansfield, T.A., Judson, R.S., Knight, J.R., Lockshon, D., Narayan, V., Srinivasan, M., Pochart, P., Qureshi‐Emili, A., Li, Y., Godwin, B., Conover, D., Kalbfleisch, T., Vijayadamodar, G., Yang, M., Johnston, M., Fields, S., and Rothberg, J.M. 2000. A comprehensive analysis of protein‐protein interactions in Saccharomyces cerevisiae. Nature 403:623‐627. |
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