如题,看文献cross-presentation of cell,是指哪类细胞,和APCs(抗原提呈细胞)是什么关系?谢谢
The term cross-presentation denotes the ability of certain antigen-presenting cells to take up, process and present extracellular antigens with MHC class I molecules to CD8 T cells (cytotoxic T cells). Cross-priming describes the stimulation of naive cytotoxic CD8+ T cells by this process[1]. This process is necessary for immunity against most tumors and against viruses that do not infect antigen-presenting cells.[2][3]
详见:http://en.wikipedia.org/wiki/Cross-presentation
Dendritic cell have the unique ability to capture extracellular antigen and load to MHC1 then cross prime CD8 T cell. it was reported that some other cells such as macrophage and some endothelial cell in specific tissue have this ability as well.
I remember a paper reported that macrophage infected with bacterial such as mycobacteria can present bacterial antigen to MHC2 and prime CD8 T cell which represent a detour antigen presentation pathway. I am not sure if this is another kind of cross presentation.