HSV Vectors for Gene Therapy
互联网
625
A number of aspects of the natural biology of herpes simplex virus (HSV) make it an attractive candidate for a vector to express foreign genes within the nervous system. Some of the advantages of an HSV vector are
| 1 |
Establishment of a life-long latent infection within peripheral and central nervous system neurons (for a review, see ref,1 );
|
| 2 |
Latent HSV genomes exist as multiple episomal copies/neuron and integration is not known to occur (2 ), and
|
| 3. |
Nonreplicating HSV recombinants can establish a latent infection efficiently (3 )
|
