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HSV Vectors for Gene Therapy

互联网

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A number of aspects of the natural biology of herpes simplex virus (HSV) make it an attractive candidate for a vector to express foreign genes within the nervous system. Some of the advantages of an HSV vector are
Establishment of a life-long latent infection within peripheral and central nervous system neurons (for a review, see ref,1 );
Latent HSV genomes exist as multiple episomal copies/neuron and integration is not known to occur (2 ), and
3. 
Nonreplicating HSV recombinants can establish a latent infection efficiently (3 )
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