CD57分子

CD57

Aka Leu7

Glycoprotein with cell adhesion functions

NK cell marker and neuroendocrine marker

Subset of NK cells (note: NK cells have no TCR membrane expression or gene rearrangement)

CD16+, CD57-: substantial NK activity

CD16-, CD57-: no NK activity

CD16-, CD57+: weak NK activity

CD16+, CD57+: variable NK activity

Associated with poor prognosis in nasal lymphomas

Positive staining (normal): NK subset, T cell subset (CD2,3,5), neuroectodermal tissue, brain, prostate, proximal tubules of kidney

Positive staining (tumors): neuroectodermal tumors, small cell lung cancer (some), prostatic adenocarcinoma, nerve sheath origin lesions, metanephric adenoma, renal carcinoid tumors, some clear cell renal cell carcinomas, spindle cell thymomas (AJSP 2001;25:111, lymphomas (some)

Micro images (AJSP subscribers): metanephric adenoma (figure 4C), Wilms tumor #1 (figure 5C), #2 (figure 6C), dendritic cell neurofibroma with pseudorosettes

Reference: AJSP 2001;25:587, AJSP 2001;25:1290