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Transgenic Animal Mutation Models: A Review of the Models and How They Function

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In regulatory genetic toxicology, the endpoints available for routine study in vivo have been limited to looking at chromosomal damage or unscheduled DNA synthesis in a very limited number of tissues. With the development of transgenic gene mutation systems in rodents came the opportunity to investigate a new endpoint. The better-known λLacI and λLacZ are covered in some detail and the less well established models do receive mention with appropriate references for those wishing more information. Using a recommended experimental design it is now possible to look at the ability of a compound to induce gene mutation following in vivo exposure, in any tissue from which suitable DNA can be isolated.
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