Acid—Base Balance
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Changes of cerebral acid-balance, notably of extracellular pH (pHe ), have long attracted the attention of physiologists. This is mainly because both cerebral blood flow (CBF) and pulmonary ventilation are exquisitely sensitive to alterations in pHe , whether these are caused by changes in pCO2 or by addition of strong acid or base to cerebral extracellular fluids (see reviews by Kuskchinsky and Wahl, 1978; Siesj� and Ingvar, 1983).
