Molecular Cytogenetics in Reproductive Pathology
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Conventional cytogenetic analysis has contributed for the last 35 yr to establishing the etiology of spontaneous abortions (SAs), representing an important diagnostic aid for reproductive pathologists, geneticists, and physicians. There is however a problem in obtaining a cytogenetic result from 10–30% of abortion specimens owing to culture failure. In addition, growth of maternally-derived cells in culture can result in a false negative result. Nowadays, new molecular cytogenetic tools are available to get cytogenetic information in almost all cases of SA submitted to the Cytogenetics laboratory.
