CD18分子
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CD18 分子
CD18
常用单克隆抗体或代号： MHM23;(LFA组b 链,integrin b 2,CR3)
主要表达细胞： Leu [AS]
分子质量(kDa)和结构： gp95
功 能： ICAM- 1(CD54)、ICAM- 2(CD102)、ICAM- 3、C3bi配体,粘附,调理吞噬
CD18
Forms the beta 2 chain of CD11a, b, c (leukocyte adhesion molecule)
Important for adhesion and signaling in the hemaoietic system (see CD11 a-c above)
Leukocyte Adhesion Deficiency (LAD-1) caused by CD18 defect coding for common b2 subunit; patients suffer from recurrent infections
Positive staining: leukocytes
