Analysis of Linker Histone Binding to Mono- and Dinucleosomes
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The assembly of DNA into the eukaryotic nucleus via an ascending hierarchy of intermediate chromatin structures has two major functional consequences:
| 1. |
The intermediate chromatin structures provide a filing system that greatly facilitates the search by RNA polymerase for regulatory DNA and the associated trans-acting factors.
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| 2. |
The wrapping of DNA around the histones provides a means of compacting a large mass of DNA containing many genes while retaining specific sequences in an exposed and accessible state.
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