CD73分子
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CD73 分子
CD73
常用单克隆抗体或代号： 7G2.2.11,AD- 2
主要表达细胞： Bsub,Tsub,En [B]
分子质量(kDa)和结构： p69(GPI连接）
功 能： 5’-核苷酸外切酶,T细胞活化
CD73
Aka ecto-5-nucleotidase, PI-linked
Catalyses dephosphorylation of purine and pyrimidine ribo- and deoxyribonucleoside monophosphates to their corresponding nucleosides
Mediates costimulatory signals in T cell activation, lymphocyte adhesion to endothelium
May be lymphocyte maturation marker
High levels are poor prognostic factors in leukemia/lymphomas
Positive staining (normal): B and T cell subset; endothelial cells, on follicular dendritic cells, epithelial cells
Positive staining (disease): acute T cell leukemia, CLL, ALL
