Rapid Liquid-Phase Combinatorial Synthesis of Heterocyclic Libraries
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Over the past few years, combinatorial chemistry has emerged as an exciting new approach to discover novel drug candidates. It contains many tactics and processes for the rapid synthesis of large, organized collections of lowmolecular-weight compounds without tedious and time-consuming purification. In combination with high-throughput screening, combinatorial organic synthesis of pharmaceutically interesting molecules may revolutionize the drug discovery program. Combinatorial chemistry has become increasingly popular in academic institutes and industries. It has been reported (1 ) that in the early years of 1992−1998, 63% contributors of combinatorial chemistry were from industry and 37% from academic laboratories. In the past two years, both academic institutes and pharmaceutical companies have developed novel combinatorial techniques for library synthesis equally. The majority of academic publications showed new synthetic methodologies; however, pharmaceutical companies used this technique for rapid screening and synthesizing of biologically active compounds.